Atmospheric refractivity effects on mid-infrared ELT adaptive optics

We discuss the effect of atmospheric dispersion on the performance of a mid-infrared adaptive optics assisted instrument on an extremely large telescope (ELT). Dispersion and atmospheric chromaticity is generally considered to be negligible in this wavelength regime. It is shown here, however, that with the much-reduced diffraction limit size on an ELT and the need for diffraction-limited performance, refractivity phenomena should be carefully considered in the design and operation of such an instrument. We include an overview of the theory of refractivity, and the influence of infrared resonances caused by the presence of water vapour and other constituents in the atmosphere. `Traditional' atmospheric dispersion is likely to cause a loss of Strehl only at the shortest wavelengths (L-band). A more likely source of error is the difference in wavelengths at which the wavefront is sensed and corrected, leading to pointing offsets between wavefront sensor and science instrument that evolve with time over a long exposure. Infrared radiation is also subject to additional turbulence caused by the presence of water vapour in the atmosphere not seen by visible wavefront sensors, whose effect is poorly understood. We make use of information obtained at radio wavelengths to make a first-order estimate of its effect on the performance of a mid-IR ground-based instrument. The calculations in this paper are performed using parameters from two different sites, one `standard good site' and one `high and dry site' to illustrate the importance of the choice of site for an ELT.Comment: 11 pages, to be published in SPIE Proceedings vol. 7015, Adaptive Optics Systems, eds. N. Hubin, C.E. Max and P.L. Wizinowich, 200

Wavelength calibration of the JWST-MIRI medium resolution spectrometer

We present the wavelength and spectral resolution characterisation of the Integral Field Unit (IFU) Medium Resolution Spectrometer for the Mid-InfraRed Instrument (MIRI), to fly onboard the James Webb Space Telescope in 2014. We use data collected using the Verification Model of the instrument and develop an empirical method to calibrate properties such as wavelength range and resolving power in a portion of the spectrometer's full spectral range (5-28 microns). We test our results against optical models to verify the system requirements and combine them with a study of the fringing pattern in the instrument's detector to provide a more accurate calibration. We show that MIRI's IFU spectrometer will be able to produce spectra with a resolving power above R=2800 in the wavelength range 6.46-7.70 microns, and that the unresolved spectral lines are well fitted by a Gaussian profile.Comment: 12 pages, submitted to SPIE Proceedings vol. 7731, Space Telescopes and Instrumentation 2010: Optical, Infrared, and Millimeter Wav

Unproceedings of the Fourth .Astronomy Conference (.Astronomy 4), Heidelberg, Germany, July 9-11 2012

The goal of the .Astronomy conference series is to bring together astronomers, educators, developers and others interested in using the Internet as a medium for astronomy. Attendance at the event is limited to approximately 50 participants, and days are split into mornings of scheduled talks, followed by 'unconference' afternoons, where sessions are defined by participants during the course of the event. Participants in unconference sessions are discouraged from formal presentations, with discussion, workshop-style formats or informal practical tutorials encouraged. The conference also designates one day as a 'hack day', in which attendees collaborate in groups on day-long projects for presentation the following morning. These hacks are often a way of concentrating effort, learning new skills, and exploring ideas in a practical fashion. The emphasis on informal, focused interaction makes recording proceedings more difficult than for a normal meeting. While the first .Astronomy conference is preserved formally in a book, more recent iterations are not documented. We therefore, in the spirit of .Astronomy, report 'unproceedings' from .Astronomy 4, which was held in Heidelberg in July 2012.Comment: 11 pages, 1 figure, .Astronomy 4, #dotastr

Optical performance of the JWST MIRI flight model: characterization of the point spread function at high-resolution

The Mid Infra Red Instrument (MIRI) is one of the four instruments onboard the James Webb Space Telescope (JWST), providing imaging, coronagraphy and spectroscopy over the 5-28 microns band. To verify the optical performance of the instrument, extensive tests were performed at CEA on the flight model (FM) of the Mid-InfraRed IMager (MIRIM) at cryogenic temperatures and in the infrared. This paper reports on the point spread function (PSF) measurements at 5.6 microns, the shortest operating wavelength for imaging. At 5.6 microns the PSF is not Nyquist-sampled, so we use am original technique that combines a microscanning measurement strategy with a deconvolution algorithm to obtain an over-resolved MIRIM PSF. The microscanning consists in a sub-pixel scan of a point source on the focal plane. A data inversion method is used to reconstruct PSF images that are over-resolved by a factor of 7 compared to the native resolution of MIRI. We show that the FWHM of the high-resolution PSFs were 5-10% wider than that obtained with Zemax simulations. The main cause was identified as an out-of-specification tilt of the M4 mirror. After correction, two additional test campaigns were carried out, and we show that the shape of the PSF is conform to expectations. The FWHM of the PSFs are 0.18-0.20 arcsec, in agreement with simulations. 56.1-59.2% of the total encircled energy (normalized to a 5 arcsec radius) is contained within the first dark Airy ring, over the whole field of view. At longer wavelengths (7.7-25.5 microns), this percentage is 57-68%. MIRIM is thus compliant with the optical quality requirements. This characterization of the MIRIM PSF, as well as the deconvolution method presented here, are of particular importance, not only for the verification of the optical quality and the MIRI calibration, but also for scientific applications.Comment: 13 pages, submitted to SPIE Proceedings vol. 7731, Space Telescopes and Instrumentation 2010: Optical, Infrared, and Millimeter Wav

The carbon footprint of large astronomy meetings

The annual meeting of the European Astronomical Society took place in Lyon, France, in 2019, but in 2020 it was held online only due the COVID-19 pandemic. The carbon footprint of the virtual meeting was roughly 3,000 times smaller than the face-to-face one, providing encouragement for more ecologically minded conferencing.Comment: Originated in a Twitter discussion (https://twitter.com/sarahkendrew/status/1144186571538739202) at EWASS 2019; followed up at the EAS 2020 conference sustainability session by https://astronomersforplanet.earth - published in Nature Astronomy, September 202

A transdisciplinary approach to a conservation crisis: a case study of the Eurasian curlew (Numenius arquata) in Ireland

In this article, we build on a growing literature of examples of transdisciplinary approaches to illustrate the catalysts and outcomes of a stakeholder‐driven process to conservation practice. We illustrate this using the case of one of Europe's most rapidly declining bird species, the Eurasian curlew (Numenius arquata ). As part of the response to its continuing decline, a stakeholder‐driven workshop was held in Ireland in November 2016, bringing together over 80 stakeholders from a range of governmental, non‐governmental, and private organizations responsible for or interested in curlew conservation and management. This innovative workshop sought to formulate ideas and support the implementation of actions from stakeholders themselves on how to halt further losses of curlews, within the current legislative framework. Four years on, many of the short‐ and medium‐term actions identified during the workshop have been implemented jointly by stakeholders. However, curlew recovery will require continued communication and meaningful engagement with all relevant stakeholders together with increased government support underpinned by increased public awareness and ownership of the curlew's plight. Ultimately, many stakeholders will measure the success of curlew conservation in Ireland by the long‐term viability of the breeding population

The Milky Way Project: A statistical study of massive star formation associated with infrared bubbles

The Milky Way Project citizen science initiative recently increased the number of known infrared bubbles in the inner Galactic plane by an order of magnitude compared to previous studies. We present a detailed statistical analysis of this dataset with the Red MSX Source catalog of massive young stellar sources to investigate the association of these bubbles with massive star formation. We particularly address the question of massive triggered star formation near infrared bubbles. We find a strong positional correlation of massive young stellar objects (MYSOs) and H II regions with Milky Way Project bubbles at separations of < 2 bubble radii. As bubble sizes increase, a statistically significant overdensity of massive young sources emerges in the region of the bubble rims, possibly indicating the occurrence of triggered star formation. Based on numbers of bubble-associated RMS sources we find that 67+/-3% of MYSOs and (ultra)compact H II regions appear associated with a bubble. We estimate that approximately 22+/-2% of massive young stars may have formed as a result of feedback from expanding H II regions. Using MYSO-bubble correlations, we serendipitously recovered the location of the recently discovered massive cluster Mercer 81, suggesting the potential of such analyses for discovery of heavily extincted distant clusters.Comment: 16 pages, 17 figures. Accepted for publication in ApJ, comments welcome. Milky Way Project public data release available at http://www.milkywayproject.org/dat

Therapeutic targeting of integrin αvβ6 in breast cancer

BACKGROUND: Integrin ?v?6 promotes migration, invasion, and survival of cancer cells; however, the relevance and role of ?v?6 has yet to be elucidated in breast cancer.METHODS: Protein expression of integrin subunit beta6 (?6) was measured in breast cancers by immunohistochemistry (n &gt; 2000) and ITGB6 mRNA expression measured in the Molecular Taxonomy of Breast Cancer International Consortium dataset. Overall survival was assessed using Kaplan Meier curves, and bioinformatics statistical analyses were performed (Cox proportional hazards model, Wald test, and Chi-square test of association). Using antibody (264RAD) blockade and siRNA knockdown of ?6 in breast cell lines, the role of ?v?6 in Human Epidermal Growth Factor Receptor 2 (HER2) biology (expression, proliferation, invasion, growth in vivo) was assessed by flow cytometry, MTT, Transwell invasion, proximity ligation assay, and xenografts (n ? 3), respectively. A student's t-test was used for two variables; three-plus variables used one-way analysis of variance with Bonferroni's Multiple Comparison Test. Xenograft growth was analyzed using linear mixed model analysis, followed by Wald testing and survival, analyzed using the Log-Rank test. All statistical tests were two sided.RESULTS: High expression of either the mRNA or protein for the integrin subunit ?6 was associated with very poor survival (HR = 1.60, 95% CI = 1.19 to 2.15, P = .002) and increased metastases to distant sites. Co-expression of ?6 and HER2 was associated with worse prognosis (HR = 1.97, 95% CI = 1.16 to 3.35, P = .01). Monotherapy with 264RAD or trastuzumab slowed growth of MCF-7/HER2-18 and BT-474 xenografts similarly (P &lt; .001), but combining 264RAD with trastuzumab effectively stopped tumor growth, even in trastuzumab-resistant MCF-7/HER2-18 xenografts.CONCLUSIONS: Targeting ?v?6 with 264RAD alone or in combination with trastuzumab may provide a novel therapy for treating high-risk and trastuzumab-resistant breast cancer patients.<br/